Excellent article bringing up a lot of really good points other things to be thinking about is ways to speed up proof concept and infectious disease the option of using challenge trials.
A tangential thought: I tip my hat to the necessary and productive work done by thousands to improve the clinical trial world from within "the paradigm." Undoubtedly my own personal health has a lot to thank for that. I'm also really eager to see some profound disruptions to it. I'm off on my own adventure trying to deliver our own disruption, but more broadly I hope that there are some successful game changers that allow us to re-envision the entire process more fundamentally - without sacrificing safety, efficacy, cost, time, etc. Perhaps those disruptions shift the operating envelope out favorably. Though all processes will still suffer the same constraints/bottlenecks you map out here, perhaps they can do so in an operating space that finds, for at least some subset of health, a new local environment to mine.
Excellent article bringing up a lot of really good points other things to be thinking about is ways to speed up proof concept and infectious disease the option of using challenge trials.
awesome article! The shifting bottlenecks section is insightful
Creative and impressive. Thanks.
A tangential thought: I tip my hat to the necessary and productive work done by thousands to improve the clinical trial world from within "the paradigm." Undoubtedly my own personal health has a lot to thank for that. I'm also really eager to see some profound disruptions to it. I'm off on my own adventure trying to deliver our own disruption, but more broadly I hope that there are some successful game changers that allow us to re-envision the entire process more fundamentally - without sacrificing safety, efficacy, cost, time, etc. Perhaps those disruptions shift the operating envelope out favorably. Though all processes will still suffer the same constraints/bottlenecks you map out here, perhaps they can do so in an operating space that finds, for at least some subset of health, a new local environment to mine.